Clinical value of combined detection of serum tumor markers in diagnosis of lung carcinoma

Objective To investigate the clinical value of combined detection of CEA,CA125,NSE and CYFRA 21-1 in lung cancer. Methods The levels of four tumor markers in 133 cases of primary lung cancer,56 cases of benign lung disease and 50 healthy people were assayed by electrochemiluminesence immuno-assay and were compared. Results The levels of four tumor markers in lung cancer were all significantly higher than those in benign lung diseases and normal controls (P0.01).NSE had the highest positive rate in small cell lung cancer was 71.4%,CYFRA21-1 had the highest positive rate in lung squamous carcinoma was 75.6% .Combination of four tumor markers detection make the sensitivity of the diagnosis of lung cancer by single detection were 45.1%,42.1%,35.3%,49.6% up to 84.2%,the accuracy from single detection of 64.0% , 59.4% , 60.2% , 67.9% up to 80.3% ,but no obvious decline in specific degrees. Conclusion Combined detection of serum CEA,CA125,NSE and CYFRA21-1 promote the diagnostic value of lung cancer patients and provide a reliable evidence for pathological classification.