A control study of fluvoxamine and clomipramine in the treatment of adolescents with OCD

Objective To study the efficacy and adverse reactions of fluvoxamine and clomipramine in the treatment of adolescents with OCD.Methods 42 adolescents with OCD were randomized into fluvoxamine group(21 cases) and clomipramine group(21 cases) treated with fluvoxamine and clomipramine respectively for 8 weeks.All patients were assessed with Yale-Brown Obsessive Compulsive Scale(Y-BOCS) and Hamilton Anxiety Scale(HAMA) to evaluate the efficiency and were assessed with Treatment Emergent Symptom Scale(TESS) to evaluate the side effects.Results There was no significant difference in response rate between fluvoxamine group and clomipramine group(86.4% vs.86.4%,P = 1.00).Compared with the baseline,scores of Y-BOCS and HAMA in both groups decreased significantly at the 4th,8th week of the treatment(P 0.01).The rate of adverse reactions in fluvoxamine group was significantly lower than that in clomipramine group(35% vs.70%,P 0.05).Conclusion Fluvoxamine is safe and effective in the treatment of adolescents with OCD.