Measurement of Prostoglandin E_2 and Glycosylated Hemoglobin in Gingival Crevicular Fluid from Periodontal Diseases in Diabetics

Objective To investigate prostaglandin E 2 (PGE 2) level of gingival crevicular fluid (GCF) from periodontal diseases in insulin dependent diabetes mellitus (IDDM) patients and the relationship between GCF PGE 2 concentration and metabolic disorder. Methods 28 cases IDDM periodontal disease patients and 54 cases systemically healthy person as control were studied. The contents of GCF PGE 2 were measured. The levels of glycosylated hemoglobin (HbA 1c ) in IDDM patients were analysed. Results Diabetics had significantly higher GCF PGE 2 level(μg/L) as compared to non diabetic controls (186±53 vs 46±7,346±28 vs 48±10,P0 01). Within the diabetics, the GCF PGE 2 in moderate or severe periodontal disease patients were almost 2 fold higher as compared to mild periodontal disease patients. The GCF mediators did not correlate with HbA 1c levels. Conclusions The high GCF PGE 2 may be a consequence of a systemic response trait and the increase of this mediator, on the other hand, can further deteriorate periodontal tissue in diabetics.