Effect of diabetes on levels of IL-1β and PGE2 in gingival crevicular fluid in patients with periodontitis

AIM: To investigate IL-1β and PGE2 levels in gingival crevicular fluid(GCF) from type 2 diabetes mellitus patients with periodontitis and the relationship between the concentrations of GCF-IL-1β,GCF-PGE2 and metabolic disorder.METHODS: Eighteen type 2 diabetic patients with periodontitis(DM),18 patients with periodontitis(PD) and 18 systemically and periodontally healthy control subjects(H) were enrolled.Clinical periodontal measurements were recorded,and levels of GCF-IL-1β,GCF-PGE2 and HbA1c were measured.RESULTS: All clinical periodontal measurements and GCF-PGE2 levels were higher in DM group and PD group than in H group(P0.05).DM group revealed higher GCF-IL-1β levels and HbA1c than PD group and H group(P0.05).The GCF-IL-1β levels were correlated with HbA1c.CONCLUSION: The high GCF-IL-1β may be a consequence of a systemic response trait,and it can further deteriorate periodontal tissue in diabetics.