Study on influence of Zhiweifangbian capsule on levels of NO and NOS in gastric tissues,level of gastrin in serum and content of ET-1 in plasma of rats with chronic atrophic gastritis

Objective To study effects of Zhiweifangbian capsule(ZWFB) on levels of NO and NOS in gastric tissues,level of gastrin in serum and content of ET-1 in plasma of rats with chronic atrophic gastritis(CAG).Methods CAG model of was established with synthetic method.The levels of NO and NOS in gastric tissues,level of gastrin in serum and content of ET-1 in plasma were detected.Results In model group,levels of NO and NOS in gastric tissues and content of ET-1 in plasma were much higher than those of normal group(P0.01,P0.05),level of gastrin in serum was much lower than that of normal group(P0.05).Compared with model group,ZWFB could decrease content of NO and NOS in gastric tissues and ET-1 in plasma,increase level of gastrin in serum significantly(all P0.05).Conclusions ZWFB has functions of ameliorating gastric mucosal blood flow and microcirculation,elevating antioxidation enzyme activity,lessening free radical impairment and restraining lipid peroxidation.