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2008•Journal of Tropical MedicineRequires access

Analysis of Serum Fibrosis Markers in Hepatitis Patients

Zheng-yun Tang

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Abstract

Objective To evaluate the clinical significance of serum fibrosis markers in patients with viral hepatitis. Methods Levels of serum MMP-1, TIMP-1 and TGF-β1 were measured by ELISA method. RIA was used to measure TGF-, HA, PCⅢ, C-Ⅳ and LN. Results The levels of TIMP-1, HA, PCⅢ, C-Ⅳ and LN in the hepatitis patients were higher than the control group (P0.01). The levels of MMP-1 and TGF-β1 in the hepatitis patients were not significantly different from the control group (P 0.05). Conclusion TIMP-1, HA, PCⅢ, C-Ⅳ and LN may be used as markers for detecting liver fibrosis in hepatitis patients.

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What this paper is about

Objective To evaluate the clinical significance of serum fibrosis markers in patients with viral hepatitis. Methods Levels of serum MMP-1, TIMP-1 and TGF-β1 were measured by ELISA method. RIA was used to measure TGF-, HA, PCⅢ, C-Ⅳ and LN. Results The levels of TIMP-1, HA, PCⅢ, C-Ⅳ and LN in the hepatitis patients were higher than the control group (P0.01). The levels of MMP-1 and TGF-β1 in the hepatitis patients were not significantly different from the control group (P 0.05). Conclusion TIMP-1, HA, PCⅢ, C-Ⅳ and LN may be used as markers for detecting liver fibrosis in hepatitis patients.

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Available abstract

Objective To evaluate the clinical significance of serum fibrosis markers in patients with viral hepatitis. Methods Levels of serum MMP-1, TIMP-1 and TGF-β1 were measured by ELISA method. RIA was used to measure TGF-, HA, PCⅢ, C-Ⅳ and LN. Results The levels of TIMP-1, HA, PCⅢ, C-Ⅳ and LN in the hepatitis patients were higher than the control group (P0.01). The levels of MMP-1 and TGF-β1 in the hepatitis patients were not significantly different from the control group (P 0.05). Conclusion TIMP-1, HA, PCⅢ, C-Ⅳ and LN may be used as markers for detecting liver fibrosis in hepatitis patients.

Key concepts: Medicine, Liver fibrosis, Fibrosis, Internal medicine, Gastroenterology, Viral hepatitis, Hepatitis, Hepatitis C

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