The detection of diverse tumor markers to lung carcinoma metastasis and prognosis evaluation

Objective:To investigate the combined detection of diverse tumor markers to lung carcinoma metastasis and the value of prognosis evaluation.Methods:The blood serum of 117 patients with lung carcinoma were detected by diverse tumor markers protein biochip for determining the level of 12 kinds of tumor markers(AFP,NSE,CEA,CA125,CA199,CA242,CA153,ferritin,free-PSA,PSA,β-HCG and HCG) in the blood,and in those cases,88 cases were identified as metastasis group and 29 as non-metastasis group,and prognosis was followed up.Results:The positive rate of metastasis group was 67.1%(59/88),which was evidently higher than the rate of non-metastasis 27.6%(8/29)(P=0.0002) ;after 2-year's follow-up,it was found that the death rate of patients with positive tumor markers was 95.31%(61/64),which was evidently higher than the negative group 55.56%(25/45)(P=0.0000).Conclusion:The combined detection of tumor markers can be used as index of clinical criterion of lung carcinoma metastasis,and that is significant to prognosis evaluation.