Fleroxacin vs ciprofloxacin in treatment of bacterial infection

To evaluate the efficacy and safety of fleroxacin injection vs ciprofloxacin injection in treatment of acute bacterial infection. METHODS: One hundred and twenty-two patients with respiratory and urinary tract infections were randomly divided into 2 groups, 61 patients were treated with fleroxacin; 61 patients were treated with ciprofloxacin. Another 40 Patients treated with flexoxacin as open treated group. All were 0. 2-0. 4 g iv drip, qd (fleroxacin) or bid (ciprofloxacin) for 714 d. RESULTS: The overall clinical efficacy rates of fleroxacin was 93. 1 % (94/101 ). The randomized comparison showed that the clinical efficacy rates of fleroxacin and ciprofloxacin were similar 92% (56/ 61) vs 82% (50/61 ), P 0. 05, but the bacterial clearance rate for fleroxacin(94% ) was higher than that for ciprofloxacin (86%, P0. 05). The incidence of adverse reactions for fleroxacin and ciprofloxacin were 6 % and 8 %, respectively (P 0. 05). CONCLUSION: Fleroxacin injection is an effective and Safe antihacterial for treatment of bacterial infection.