A Clinical Control Study on ALA-PDT Combined with CO_2 Laser Therapy in the Treatment of Condyloma Acuminatum

Objective To find out the clinical differences between three kinds of therapies in treating condyloma acuminatum:ALA-PDT combined with CO2 laser,ALA-PDT only and CO2 laser only.Method One hundred and twenty cases of condyloma Acuminatum are separated randomly into three groups with 40 cases for each group.Three groups were treated respectively by ALA-PDT combined with CO2 laser,ALA-PDT or CO2 laser.Results The cure rate,effective rate and recurrence rate using ALA-PDT alone was 42.50%(17/40),65.00%(26/40),29.17%(7/24).The clearance rate,cure rate and recurrence rate was 100%(40/40),37.50%(15/40),62.50%(25/40)respectively using CO2 laser alone.The clearance rate,cure rate and recurrence rate was 100%(40/40),90.00%(36/40),10.00%(4/40)respectively using ALA-PDT combined with CO2 laser.Compared the cure rate and recurrence rate in three groups,ALA-PDT combined with CO2 laser is better than ALA-PDT only or CO2 laser only.The discrepancy has significance in statistics(all P0.001).Conclusions The method of ALA-PDT combined with CO2 laser has a lower relapse rate and its effect is better than ALA-PDT or CO2 laser only.It can be applied widely due to its obvious effectiveness.