Clinical Comparative Study of Local Mild Hypothermia on Treating Cerebral Hemorrhage

Objective To study the effect of local mild hypothermia on the prognosis of patient with cerebral hemorrhage. Methods A local hypothermia was given to the hemisphere on the hemorrhage side of cerebral hemorrhage. The preparing temperature of cryostat was 8 ℃～12 ℃ and the temperature of the intracranial area was about 33 ℃. The duration of temperature was 72 hours. The neural functional deficit of patient was calculated before and at 5, 14 days after the treatment. Meanwhile, the serum neuron-specific enolase (NSE) was measured before and at 3, 5 days after the treatment, both were compared with the control group. Results The score of neural functional deficit in the treatment group was significantly higher than that of the control group, which were 54.12±11.22, 54.91±10.07 and 39.16±8.71 on the 5th day, 77.24±20.32, 75.23±19.36 and 51.41±12.43 on the 14th day respectively P0.05. The NSE was significantly different which were 15.53±4.93, 16.21±5.24 and 20.26±9.04ng/ml on the 3rd day, and 12.32±4.03, 14.07±4.31 and 18.12±5.97ng/ml on the 5th day respectively P0.01. Conclusion The local mild hypothermia might have a tangible protective effect to the tissue of the brain and no obvious complication was observed.