The Influence of Local Mild-hypothermia Therapy on Cerebral Blood Flower in the Patients with Acute Cerebral Hemorrhage and Its Clinical Signification

Objective To study the influence of focal mild hypothermia on the regional cerebral blood flower in the patients with acute cerebral hemorrhage and to explore its clinical significance and mechanism.Methods 36 patients with acute cerebral hemorrhage were divided randomly into local mild hypothermia group and routine therapy group with mannitol.There were 19 and 17 cases in the former and latter group respectively,and the former group were treated with local mild hypothermia for 72 h based on routine therapy.The control group was 20 healthy people.The regional cerebral blood flower was determined by Single-Photon Emission Computed Tomography(SPECT)at 4th day.And the clinical status was evaluated by NIHSS dynamically before treatment and at 3rd,7th,14th and 21st day after the treatment.Results The regional cerebral blood flower in patients with acute cerebral hemorrhage was lower than that in healthy peoples(P0.05).Compared with routine therapy group,The regional cerebral blood flower was increased in local mild hypothermia group significantly(P0.05),and the NIHSS was apparently improved at 14 and 21 day after the treatment(P0.05).Conclusions The local mild hypothermia therapy could dramatically increase the regional cerebral blood flower,alleviate the severity of the damaged neurons,protect and improve neurological function in the patients with acute cerebral hemorrhage.