Chemical constituents in root barks of Lycium chinense

Objective To study the chemical constituents from the root barks of Lycium chinense. Methods The chemical constituents of EtOAc fraction from 95% ethanol extract of L. chinense were isolated and purified by chromatography on silica gel, Sephadex LH-20, and ODS. Their chemical structures were identified on the basis of physicochemical properties and spectroscopic data. Results Twelve compounds were isolated and identified as N-trans-coumaroyltyramine(1), N-trans-feruloyltyramine(2), dihydro-N-caffeoyltyramine(3), apigenin(4), ferulic acid(5), p-hydroxycinnamic acid(6), 3-hydroxy-1-(4-hydroxyphenyl)-1-propanone(7), 3, 4-dihydroxybenzenepropionic acid(8), 3, 4-dihydroxybenzenepropionic acid methyl ester(9), p-hydroxy-benzoic acid(10), 4-methoxy salicylic acid(11), and nicotinic acid(12). Conclusion Compounds 8 and 9 are two new natural products, and compounds 1, 6, 11, and 12 are obtained from this plant for the first time.