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Detection and Its Significance of Serum Leptin and Ferritin in Childhood Acute Lymphoblastic Leukemia

Sheng Guang-yao

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Abstract

Objective To explore the dynamic changes of serum leptin and ferritin(SF) levels in children with acute lymphoblastic leukemia(ALL) and to find out the correlations between serum leptin and SF and the childhood acute lymphoblastic leukemia.Method Serum leptin and SF of children with ALL and control subjects were measured by enzyme-linked immunoadsurbent assay(ELISA).Results Before chemotherapy the levels of serum leptin of every group were lower significantly than those of normal control group(P0.01).Before chemotherapy the levels of SF of every group were significantly higher than those of control subjects(P(0.01)).After chemotherapy the levels of serum leptin and SF were markedly reduced than before.Conclusion The change of serum leptin and SF levels can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of children with ALL.J Appl Clin Pediatr,2006,21(3):162-163

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Objective To explore the dynamic changes of serum leptin and ferritin(SF) levels in children with acute lymphoblastic leukemia(ALL) and to find out the correlations between serum leptin and SF and the childhood acute lymphoblastic leukemia.Method Serum leptin and SF of children with ALL and control subjects were measured by enzyme-linked immunoadsurbent assay(ELISA).Results Before chemotherapy the levels of serum leptin of every group were lower significantly than those of normal control group(P0.01).Before chemotherapy the levels of SF of every group were significantly higher than those of control subjects(P(0.01)).After chemotherapy the levels of serum leptin and SF were markedly reduced than before.Conclusion The change of serum leptin and SF levels can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of children with ALL.J Appl Clin Pediatr,2006,21(3):162-163

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Available abstract

Objective To explore the dynamic changes of serum leptin and ferritin(SF) levels in children with acute lymphoblastic leukemia(ALL) and to find out the correlations between serum leptin and SF and the childhood acute lymphoblastic leukemia.Method Serum leptin and SF of children with ALL and control subjects were measured by enzyme-linked immunoadsurbent assay(ELISA).Results Before chemotherapy the levels of serum leptin of every group were lower significantly than those of normal control group(P0.01).Before chemotherapy the levels of SF of every group were significantly higher than those of control subjects(P(0.01)).After chemotherapy the levels of serum leptin and SF were markedly reduced than before.Conclusion The change of serum leptin and SF levels can be used as a helpful indicator to evaluate the therapeutic effect and monitor the relapses and metastasis of children with ALL.J Appl Clin Pediatr,2006,21(3):162-163

Key concepts: Leptin, Medicine, Internal medicine, Lymphoblastic Leukemia, Chemotherapy, Endocrinology, Leukemia, Ferritin

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