Clinical Research on Preemptive Analgesia of Different doses of Dezocine on Patients Treated with Laparoscopic Gynecological Surgery

Objective: To observe the postoperative analgesia of different doses of dezocine in gynecological laparoscopic operation. Methods: Ninety ASAⅠ-Ⅱ patients aged 20-60 years, undergoing the gynecological laparoscopic operation were randomly divided into three groups, 30 in each group. Patients in group A received dezocine 0.1mg/kg intravenous injection 15 minutes before skin incision; patients in group B received dezocine 0.15mg/kg intravenous injection 15 minutes before skin incision; patients in group C received dezocine 0.2mg/kg intravenous injection 15 minutes before skin incision. The postoperative analgesic effects were estimated by Visual Analogue Scale(VAS). Additional analgesics and adverse effects were recorded. Results: The VAS scores of group B and C were significantly lower than those of group A at 2h, 4h, 6h and 8h after surgery(P0.05). The Ramsay scores of group A and B were significantly higher than those of group C at 2,4 h after surgery(P0.05). The application rate of additional analgesics of group B and C were significantly lower than that of group A(P0.05). No significant difference of the incidence of adverse effects was found among the three groups(P0.05). Conclusion: 0.15mg/kg dezocine intravenous injection 15 minutes before skin incision could provide satisfying postoperative analgesia in patients undergoing gynecological laparoscopic operation and had lower incidence of adverse effects.