Efficacy of dezocine for preemptive analgesia in gynecological laparoscopy

Objective To observe the preemptive analgesic effect of dezocine on gynecological laparoscopy. Methods Forty patients(ASA Ⅰ -Ⅱ )were randomly assigned into two groups.The patients in group A(n=20) received intravenous injection of dezocine 10 mg 15 min before surgery,and those in group B (n=20) intravenous injection of dezocine 10 mg 15 min before the end of surgery.Postoperative analgesia efficacy was assessed by visual analog scales(VAS) at 2,4,8,12 and 24 h after surgery.Analgesic therapy and adverse effects were evaluated after surgery. Results VAS was lower in the group A[(1.7±0.6),(1.5±0.5),(1.2±0.5),(4.1±0.9),(1.2±0.4)] at 2,4,8,12,24 h (P＜0.05) than that in group B [(2.9:±1.3),(2.8±1.7),(3.0±.2.3),(4.2±0.8),(1.8±0.7)].There was no significant difference between the two groups in adverse effects (P＞0.05). Conclusions Dezocine for preemptive analgesia can effectively relieve postoperative pain in patients with gynecological laparoscopy,and can not increase the incidence of adverse effects. Key words: Dezocine; Preemptive analgesia; Laparoscopy