Effect of Tongmai Huazhuo Decoction on the Level of Apolipoprotein in the Serum of Atherosclerosis Rats

Objective:To observe the effect of Tongmai Huazhuo(TMHZ)decoction on the level of apolipoprotein A-I(apoA-I)and apolipoprotein B-100(apoB-100)in the serum of atherosclerosis(AS)rats,and discuss its effect and mechanism to resist AS.Method:144 SD rats were randomized into six groups:normal group,model group,low-dose TMHZ decoction group,middle-dose TMHZ decoction group,high-dose TMHZ decoction group and control group of western medicine.Rats from the normal group were fed with standard chow and lavaged with normal saline,while rats from the rest groups were lavaged with vitamin D 3.7×106IU/kg for 3 days and fed with high fat chow to induce AS models of rats.After 7,14 and 28 days,at each time point rats were sacrificed to take sample.Then the levels of apoA-I and apoB-100 were tested by ITM Immunoturbidimetry.Result:There was no statistical significance between model group and TMHZ decoction group.Conclusion:TMHZ decoction can reduce AS rats' level of apoB-100,while increase their level of apoA-I,and through regulating the level of apolipoprotein,it corrects lipid metabolic disturbance,resisting AS.