Effect of Ramipril on plasma concentration of IL-1β in acute lung injury

Objective To explore change of IL-1β in plasma in lipopolysaccharide (LPS)_induced acute lung injury(ALI),and influence of Ramipril on IL-1 β and ALI.Methods SD rats were injected LPS(6 mg/kg) by peritoneum cavity to make the model of ALI.84 SD rats were divided randomly into three groups:control group,LPS group and RAM group (n=28 each).After LPS injection 0,1,3 and 5 hours,detected the plasma concentration of IL-1β in rats by radioimmunoassay,observed the changes of rats of lung tissue in pathomorphology.Results Compared with the control group,the plasma concentration of IL-1β in the LPS group at the end of 1 hour elevated significantly (P0.01),and the observation of the pathomorphology in lung tissue showed that the injury at the end of different time points were serious gradually.The plasma concentration of IL-1β at the end of 1 hour was significantly lower in the RAM group than in the LPS group (P0.01),and the lung injury at the end of different time points were slight,too.Conclusions IL-1β plays critical role in the LPS_induced ALI and Ramipril has the effect on opposition to IL-1β and relieving significantly LPS_induced ALI.