Propofol attenuates the level of TNF-α,IL-1β and IL-10 in LPS-induced acute lung injury in rats

Objective To investigate the effects of propofol aftertreatment on serum production of TNF-α,IL-1β and IL-10 in lipopolysaccharide-induced acute lung injury rats.Methods Ninty-six male SD rats were randomly divided into 4 equal groups(n=24): control group(group A);LPS group(group B);LPS+ low dose of propofol group(group C);LPS+ large dose of propofol group(group D).5 mg/kg LPS was infused through the vena caudalis to produce ALI model.In group C and D,2 and 4 mg/kg propofol was infused respectively,maintained with 4 or 8 mg·kg-1·h-1.0.9% saline was administered in group A and B.The samples of arterial blood were collected to measure the level of TNF-α,IL-1β and IL-10 at the time of 1 h,2 h,3 h and 4 h after LPS infused(saline in group A).Results The level of TNF-α,IL-1β and IL-10 in group A was significantly lower than that in other groups at all time points(P0.05 or P0.01).In group C and D,the production of TNF-α,IL-1β and IL-10 was obviously lower than that in group B 1 h or 2 h after LPS administration(P0.01).At the time of 3 and 4hr after LPS infused,IL-β and IL-10 expression in group C and D was significantly lower than that in group B(P0.01).Compared with group C,the IL-1β and IL-10 level in group D decreased significantly at all time points(P0.05 or P0.01).Conclusion Treatment with propofol can significantly inhibit the increase of TNF-α,IL-1β and IL-10 after LPS-induced acute lung injury in rats.