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2004•Unpublished venueRequires access

Effect of Tetramethylpyrazine Injection on Proliferation of Glomerulus Mesangium Cells in Rats

Xiao Jian-wu

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Abstract

Objective:To explore the inhibitory effect of tetramethylpyrazine (TMP) on proliferation of glomerulus mesangial cells (GMCs) in rats. Methods:Rat GMCs lines were cultured in vitro, Lipoplysa ccharide (LPS) and TMP with different concentration were added in the culture me dium. There were three experimental groups, GMCs+LPS+TMP,GMCs+LPS, and GMCs named as group TMP,LPS and GMCs, respectively. GMCs proliferative rate was dete rmined by MTT. Results:In TMP group,the GMCs proliferative rate were s ignificantly lower than in LPS group or in GMCs group (P0.01). Conclusion:It suggests that TMP can effectively inhibit the proliferation of GMCs.

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What this paper is about

Objective:To explore the inhibitory effect of tetramethylpyrazine (TMP) on proliferation of glomerulus mesangial cells (GMCs) in rats. Methods:Rat GMCs lines were cultured in vitro, Lipoplysa ccharide (LPS) and TMP with different concentration were added in the culture me dium. There were three experimental groups, GMCs+LPS+TMP,GMCs+LPS, and GMCs named as group TMP,LPS and GMCs, respectively. GMCs proliferative rate was dete rmined by MTT. Results:In TMP group,the GMCs proliferative rate were s ignificantly lower than in LPS group or in GMCs group (P0.01). Conclusion:It suggests that TMP can effectively inhibit the proliferation of GMCs.

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Available abstract

Objective:To explore the inhibitory effect of tetramethylpyrazine (TMP) on proliferation of glomerulus mesangial cells (GMCs) in rats. Methods:Rat GMCs lines were cultured in vitro, Lipoplysa ccharide (LPS) and TMP with different concentration were added in the culture me dium. There were three experimental groups, GMCs+LPS+TMP,GMCs+LPS, and GMCs named as group TMP,LPS and GMCs, respectively. GMCs proliferative rate was dete rmined by MTT. Results:In TMP group,the GMCs proliferative rate were s ignificantly lower than in LPS group or in GMCs group (P0.01). Conclusion:It suggests that TMP can effectively inhibit the proliferation of GMCs.

Key concepts: Tetramethylpyrazine, Chemistry, In vitro, Molecular biology, Pharmacology, Biochemistry, Medicine, Biology

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Effect of Tetramethylpyrazine Injection on Proliferation of Glomerulus Mesangium Cells in Rats — Research Paper | ScholarLens