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Expression and significance of COX-2 and NF-κB in cervical cancer

Liu Fu-min

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Abstract

Objective:To investigate the expression and significance of COX-2 and NF-κB in cervical cancer.Methods:Immunohistochemical method was applied to examine the expression of COX-2 and NF-κB,in 20 normal and 68 cervical cancer tissues.Results: COX-2 was detected in 43 of 68(63.24%) cervical cancer tissues,but 15% in normal cervix tissues;the expression of COX-2 in the two groups was significantly different(χ2=14.41,P0.01);NF-κB was detected in 49 of 68(72.06%) cervical cancer tissues,but 10% in normal cervix tissues;the expression of NF-κB in the two groups was significantly different(χ2=24.43,P0.01).COX-2 and NF-κB expression in cervical cancer tissues was significantly higher than that in normal cervical tissues,and was associated with clinical stage,pathological grade,lymph node metastasis,but not associated with patient's age and histological type.Conclusion:COX-2 and NF-κB may play an important role in the oncogenesis and development of cervical carcinoma.

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Objective:To investigate the expression and significance of COX-2 and NF-κB in cervical cancer.Methods:Immunohistochemical method was applied to examine the expression of COX-2 and NF-κB,in 20 normal and 68 cervical cancer tissues.Results: COX-2 was detected in 43 of 68(63.24%) cervical cancer tissues,but 15% in normal cervix tissues;the expression of COX-2 in the two groups was significantly different(χ2=14.41,P0.01);NF-κB was detected in 49 of 68(72.06%) cervical cancer tissues,but 10% in normal cervix tissues;the expression of NF-κB in the two groups was significantly different(χ2=24.43,P0.01).COX-2 and NF-κB expression in cervical cancer tissues was significantly higher than that in normal cervical tissues,and was associated with clinical stage,pathological grade,lymph node metastasis,but not associated with patient's age and histological type.Conclusion:COX-2 and NF-κB may play an important role in the oncogenesis and development of cervical carcinoma.

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Available abstract

Objective:To investigate the expression and significance of COX-2 and NF-κB in cervical cancer.Methods:Immunohistochemical method was applied to examine the expression of COX-2 and NF-κB,in 20 normal and 68 cervical cancer tissues.Results: COX-2 was detected in 43 of 68(63.24%) cervical cancer tissues,but 15% in normal cervix tissues;the expression of COX-2 in the two groups was significantly different(χ2=14.41,P0.01);NF-κB was detected in 49 of 68(72.06%) cervical cancer tissues,but 10% in normal cervix tissues;the expression of NF-κB in the two groups was significantly different(χ2=24.43,P0.01).COX-2 and NF-κB expression in cervical cancer tissues was significantly higher than that in normal cervical tissues,and was associated with clinical stage,pathological grade,lymph node metastasis,but not associated with patient's age and histological type.Conclusion:COX-2 and NF-κB may play an important role in the oncogenesis and development of cervical carcinoma.

Key concepts: Medicine, Cervical cancer, Immunohistochemistry, Pathological, Cervix, Carcinogenesis, Pathology, Stage (stratigraphy)

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