Expressions and significance of p27 and bcl-2 in endometrial hyperplasia and endometrial carcinoma

Objective To study the expression of p27 and bcl-2 in the endometrial hyperplasia, endometrial carcinoma and the relationship between the expression and the clinic pathological parameter. Methods S-P method was used to examine the expression of the p27 and bcl-2 in the 24 endometrial(simple and complex) hyperplasia, 20 endometrial atypical hyperplasia and 56 endometrial carcinoma. Results 1.the expression of p27 was no significance difference among the three sets(P0.05). to match with atypical hyperplasia and endometrial carcinoma, the expression of bcl-2 in the simple hyperplasia and complex hyperplasia has a significant difference(P0.05), there was no significance difference between atypical hyperplasia and endometrial carcinoma(P0.05). 2.the expression of p27 is related with the clinical stage, histological grade and muscle invasion(P0.05), and the expression is not related with pathological type and lymphnode metastasis(P0.05), the expression of bcl-2 is related to lymphnode metastasis(P0.05) and not related with other clinic pathological parameter(P0.05). 3.the expression of p27 and bcl-2 is positive correlated(P0.05). Conclusion p27 and bcl-2 play roles in different stage of the development of the endometrial carcinoma. bcl-2 may predicting the occurrence of the endometrial carcinoma in the early stage, the low expression of p27 is associated with the development of endometrial carcinoma and may be regarded as a useful index for prognosis. together inspected p27and bcl-2 has important effect in diagnosing early endometrial cacinoma, comfirming degree of malignency and forcasting prognosis.