The clinical significanse of serum markers of renal function and microalbuminuira in early diagnosis of diabetic nephropathy

Objective:To investigate the clinical significanse of serum cystatin C,serum creatinine,blood Urea nitrogen and microalbuminuira in diagnosing diabetic nephropathy.Methods: A total of 117 patients diagnosed with type 2 diabetes separated into 3 groups by the diffierent levels of HbA1c.These groups had serum creatinine and blood Urea nitrogen measured with ankyrin method,cystatin C and microalbuminuira measured with turbidimetry method.Results: The level of serum creatinine in diabetic group C was significantly higher than that in control group(P0.05).The levels of blood Urea nitrogen in diabetic group B and group C were significantly higher than those in control group(P0.05).The levels of cystatin C in all of diabetic groups were significantly higher than those in control group(P0.05).The serum cystatin C level had significantly positive correlation with microalbuminuira in diabetic group C(P0.05).Conclusion: Co-detection of cystatin C,serum creatinine,blood Urea nitrogen and microalbuminuira has important significance to early diagnosis of DM nephropathy.CysC is a sensitive maker for renal impairment in patients with diabetic nephropathy.