Study on relationship between serum P-selectin and severity of coronary lesion

Objective:To study the relationship between serum P-selectin and coronary heart disease.Methods:Three groups included 32 cases of acute coronary syndrome,38 ones of stabile coronary heart disease and 30 ones of normal coronary artery.The level of their serum P selectin was measured by enzyme-linked immunosorbent assay,the severity and extent of coronary lesion was analyzed by coronary angiography and evaluated by means of Gensini coronary score system.Results:The level of serum P-selectin increased in coronary heart disease group as compared with normal group.Meanwhile,the level of serum P-selectin also increased in acute coronary syndrome group as compared with stabile coronary heart disease group. No correlation was found between the severity of coronary lesion and the level of serum P-selectin.Conclusion:Serum P-selectin may be a marker of coronary heart disease,and measurement of this marker may be helpful to diagnosis of coronary plaque destabilization and the severity of coronary heart disease.