Observation of clinical efficacy and safety of nasopharyngeal carcinoma treated with radiotherapy combined cytokine-induced killer cells therapy

Objective To analyze the clinical efficacy and safety of nasopharyngeal carcinoma treated with radiotherapy combined combined cytokine-induced killer cells therapy. Methods Sixty cases of patients with nasopharyngeal carcinoma(NPC) from June 2010 to June 2013 in our hospital were selected as the research objects, and were divided into experimental group and control group by random number table method. The 30 cases in control group were given radiotherapy, and the another 30 cases in experimental group were given cytokine-induced killer cell therapy combined with radiotherapy. And then immune indexes and Karnofsky scores in both groups were observed. Results After 4 weeks treatment, CD4+/CD8+ratio, the percentages of Treg cells, the percentages of NK cells and NKT cells in both groups were obviously improved. Compared to the control group, the percentages of Treg cells and NKT cells in experimental group increased more obviously, while CD4+/CD8+ratio and NK cells percentage decreased more significantly with statistical differences(P0.05). The Karnofsky score in experimental group was better than that in control group with statistically significant difference(P0.05). Conclusion The cytokine-induced killer cells with radiation therapy can effectively improve the patient's immune function as well as the quality of life, which is worthy of further clinical application.