Effects of hyperlipidemia on serum levels of matrix metalloproteinase-9 and C-reactive protein in patients with cerebral infarction

Objective To explore the effects of hyperlipidemia on serum levels of matrix metalloproteinase-9(MMP-9) and C-reactive protein(CRP) in the patients with cerebral infarction(CI).Methods Testing the serum levels of MMP-9,CRP and triglyceride(TG) in 36 CI patients [with high level TG(n=18) and with normal TG(n=18)] and 17 normal controls(NC group).The relationship among the serum levels of MMP-9,CRP and TG were analysed.Results The contents of MMP-9,CRP and TG were significantly higher in CI patients with high level TG group than those in normal level TG group and NC group(all P0.01),and the contents of MMP-9 and CRP were significantly higher in CI patients with normal level TG group than NC group(all P0.01).The serum level of MMP-9 was positive corrlation with the level of CRP and TG in CI patients.The serum level of CRP was positive corrlation with the level of TG in CI patients too.But those correlationship was not found in normal controls.Conclusions The serum level of MMP-9 and CRP increase in CI patients,and the patients with high level TG increase greater.There are positive correlations among the levels of serum MMP-9,CRP and TG.