Study of correlation between infection of high risk human papillomavirus and cervical lesions

Objective To explore the relation between high-risk Human papillomavirus(hr-HPV)infection and cervical lesions.Methods The test study was carried out in which 375 women who received treatments from January 2005 to June 2006 were recruited.HPV DNA was semi-quantitatively determined by hybrid capture Ⅱ(HC-Ⅱ),then cervical biopsy was obtained under colposcope or operation and results of histopathologic tests were the final diagnoses.Results High risk HPV DNA was detected in 169 women(45.07%).Among them,infection rates of high risk HPV according to different cervical diseases were the as follows:14.67% of chronic cervicitis,50.00% of cervical intraepithelial neoplasia(CIN),including CINⅠ,CIN Ⅱand CIN Ⅲ,87.27% of cervical squamous cell carcinoma(SCC) and cervical adenocarcinoma.This rate increased from cervicitis,CIN to uterine cervix cancer(UCC),and the significant difference was observed between the groups of UCC,CIN and cervicitis(P0.05).Conclusion There is significant correlation between elevated high risk HPV DNA and severity of cervical lesion.HC-Ⅱ for detecting cervical lesion help to define the diagnosis of UCC and lesion precancerous.