Significance of Human Papillomavirus Detection in Cervical Cancer Screening

Objective:To understand the reproduction of high-risk human papillomavirus (HPV16/18) infection and cervical lesions,cervical cancer,so early detection and treatment of cervical intraepithelial neoplasia (CIN) and carcinoma in situ.Methods:The use of thin-film liquid-based cytology (TCT) technology screening with a combination of pathological diagnosis in order to cervicitis as a control group of cervicitis and high-risk patients (such as ASCUS,CIN,cervical carcinoma in situ) for a total of 685 cases HPV16/18 fluorescent detection quantitative PCR.Results:HPV16/18 infection in high-risk patients for 64.2% (124/193),in which cervical cancer,CIN Ⅲ and HPV16/18 of CIN Ⅱ infection rate 97.2% (69/71),CIN Ⅰ infection rate was 52.0% (26/50) ,ASCUS rate was 40.3% (29/72),cervicitis infection control group,11.2% (55/492),cervicitis and the results of high-risk patients compared two groups were significantly different (P0.005),High-risk patients in the infection rate of younger than 40-year-old 69.0% (40/58),older than or equal to 40-year-old rate was 62.2% (84/135),two sets of results was no significant difference (P0.05).Conclusion:HPV16/18 infection and high-risk cervical lesions,especially cervical cancer,the incidence of cervical precancerous lesions apparent relevance,and the more serious lesions,HPV infection rates higher. Cervical cancer prevention and treatment tips should focus on high-risk HPV infection and the occurrence of cervical lesions had no correlation with age.