2000•Unpublished venueRequires access
Preparation of Chiral Stationary Phase of Cellulose Trisphenylcarbamate and Resolution of Enantiomeric Compounds
Lan Zhou
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Abstract
Cellulose trisphenylcarbamate (CTPC) was synthesized by the reaction of microcrystalline cellulose with phenylisocyanate in dry pyridine at 100℃.A chiral stationary phase (CSP) was prepared by coating cellulose trisphenylcarbamate on the aminopropy1 silica.Six organic phosphonates enantiomers were resolved in normal phase system and eleven pharmaceutical enantiomers were resolved in both normal phase system and reversed phase system with high performance liquid chromatography method.Under the condition of the reversed phase system,it was found that the separation ability of the CTPC CSP in normal phase system was better than in reversed phase system.