Clinical Efficacy of Yiqi Huoluo Decoction in Patients with Early Type 2 Diabetic Nephropathy

Objective To observe the clinical efficacy of supplementing qi and activating blood circulation prescription in patients with early type 2 diabetic nephropathy.Methods A total of 40 patients of blood deficiency type with early diabetic nephropathy were selected,and randomly divided into traditional Chinese medicine treatment group and western medicine control group for 20 cases each according to the method of randomly contrast.On the basis of foundation treatment,Chinese medicine treatment group patients received San Huang Tang Shen Kang Particles(daily administration,two times orally).On the basis of foundation treatment,western medicine control group patients were given lotensin oral treatment,10 mg each time,once per day,course of 8 weeks.After completion of treatment,both of two groups of patients received general medical examination,cereal third transaminase(ALT),serum creatinine(Scr),urea nitrogen(BUN),fasting and postprandial 2 hours blood glucose,glycosylated hemoglobin,24 h urine trace albumin(U-mAlb),TCM symptoms curative effect index were determined.Results Comparing with those before treatment(0 weeks),urine trace albumin was significantly reduced in both Chinese medicine treatment group and western medicine control group(P 0.01).After 6 weeks and 8 weeks treatment,TCM syndrome integral was significantly lower in Chinese medicine treatment group than western medicine control group(P 0.05).Compared with before treatment,symptom scores were significantly lower(P 0.05 or P 0.01)at 4,6,8 weeks in both groups with statistical significance.In Chinese medicine treatment group,there were 4 patients of markedly effective,8 patients of effective,8 of non-effective,and the total effective rate was 60%.In western medicine control group there were 4 patients of markedly effective,9 patients of effective,7 of non-effective,with the total effective rate was 65%.Conclusion San Huang Tang Shen Kang particles can effectively reduce the 24 hour urine micro protein and symptom integral level in patients with early diabetic nephropathy,and it achieves the best efficacy in the first six weeks of treatment,which demonstrate ideal effects on the prevention and treatment of early diabetic nephropathy.