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2010•Chongqing yixueRequires access

Expression of COX-2 and VEGF in nasal polyps and its clinical significance

Wei An

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Abstract

Objective To discuss the expression of Cyclooxygcnase2(COX-2)and vascular endothelial growth factor(VEGF)of nasal polyps and its clinical significance.Methods Using Immunohistochcmistry Envision method,the expression of COX-2 and VEGF was examined in nasal polyps and normal nasal mucosa as well.Results(1)the expression of COX-2 in nasal polyps was significantly higher than normal nasal mucosa(P0.05).(2)the expression of VEGFin nasal polyps was significantly higher than normal nasal mucosa group(P0.05);(3)COX-2 and VEGF had the positive relation in the nasal polyps(P0.05).Conclusion COX-2 and VEGF protein in nasal polyps lay an important role,both of which have close relation in nasal polyps and may provide new target for therapy of nasal polyps.

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Objective To discuss the expression of Cyclooxygcnase2(COX-2)and vascular endothelial growth factor(VEGF)of nasal polyps and its clinical significance.Methods Using Immunohistochcmistry Envision method,the expression of COX-2 and VEGF was examined in nasal polyps and normal nasal mucosa as well.Results(1)the expression of COX-2 in nasal polyps was significantly higher than normal nasal mucosa(P0.05).(2)the expression of VEGFin nasal polyps was significantly higher than normal nasal mucosa group(P0.05);(3)COX-2 and VEGF had the positive relation in the nasal polyps(P0.05).Conclusion COX-2 and VEGF protein in nasal polyps lay an important role,both of which have close relation in nasal polyps and may provide new target for therapy of nasal polyps.

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Available abstract

Objective To discuss the expression of Cyclooxygcnase2(COX-2)and vascular endothelial growth factor(VEGF)of nasal polyps and its clinical significance.Methods Using Immunohistochcmistry Envision method,the expression of COX-2 and VEGF was examined in nasal polyps and normal nasal mucosa as well.Results(1)the expression of COX-2 in nasal polyps was significantly higher than normal nasal mucosa(P0.05).(2)the expression of VEGFin nasal polyps was significantly higher than normal nasal mucosa group(P0.05);(3)COX-2 and VEGF had the positive relation in the nasal polyps(P0.05).Conclusion COX-2 and VEGF protein in nasal polyps lay an important role,both of which have close relation in nasal polyps and may provide new target for therapy of nasal polyps.

Key concepts: Nasal polyps, Medicine, VEGF receptors, Mucous membrane of nose, Vascular endothelial growth factor, Clinical significance, Pathology, Internal medicine

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