Expression and significance of TNF-αin nasal polyps

Objective To better understand the involvement of TNF-α in the nasal polyps.The aim of this study is to detect and to localize TNF-α expression in the human nasal mucosa and nasal polyps tissue and the proportion of isoforms. Methods Nasal mucosa was obtained from patients undergoing septoplasty,and nasal polyps came from patients following polypectomy.Thirty-two cases of nasal polyps and fifteen cases of normal mucosa were studied with immunohistochemical SABC method.Results TNF-α antigen staining localized to respiratory epithelium of nasal polyps;No evidence expression in nasal mucosa.Expression of TNF-αwas also seen in inflammatory cells (P0.01).Conclusions TNF-α likely play a significant role in the pathogenesis of this disease process.there is an important significance of finding a potential treatment method.