Expression of VEGF in primary and recurrent nasal polyps

Objective To investigate the expression of vascular endothelial growth factor(VEGF)in primary and recurrent nasal polyps and to explore the probable function of it in nasal polyps pathogeneses.Methods A study was conducted on 100 cases,40 samples of primary nasal polyps,40 samples of recurrent nasal polyps,and 20 samples of inferior turbinate mucosa.Samples of inferior turbinate mucosa,as normal control,were obtained from the patients undergoing septal derivation with hypertrophic inferior turbinate.Immunohistochemistry was used to observe the espression of VEGF in there groups.Results VEGF was located mainly in the inflammatory cells under the basilar membrane and vascular endothelial cells in primary and recurrent nasal polyps.The comparison in recurrent nasal polyps was significantly higher than in primary nasal polyps(P=0.038).The comparison in primary and recurrent nasal polyps between the gender was not different.There is no obvious expression in inferior turbinate mucosa tissues.Conclusion VEGF plays very important roles in the production of tissue edema and vascular accrementition in primary and recurrent nasal polyps.The generous expression of VEGF in nasal polyps makes vessels increase,permeability enhance and inflammatory cells infiltrate.These aggravate tissue edema and accelerate the formation or recurrence of nasal polyps.