Experimental study of Ganpitiaobu Fang on immunological liver injury in mice

Objective:To study the effects of Ganpitiaobu Fang in protecting immunity hepatic injury induced by bacille calmette Guerin(BCG) and lipopolyhepatic(LPS) in mice and study on its pharmacological mechanism.Methods:The immunological liver injury rat model was produced by intraperitonealitonealinjection with BCG plus LPS.Sixty mice divied into control group,model group,low dose group,middle dose group and high dose group randomly.The levels of alanine am intransferase(ALT),aspartate an inotransferase(AST),tumor necrosis factor-a(TNF-α)in blood plasma and super oxide dismutase(SOD) of liver homogenate malondialdehyde(MDA),Glutathione peroxidase(GSH-PX) of the five groups were examined.Results:Ganpitiaobu Fang significantly reduced immunological liver injury in mice by reducing serum ALT,AST,TNF-alpha level;reducing MDA content of liver homogenate and elevated SOD,GSH-PX of contents liver homogenate.Conclusion:Ganpitiaobu Fang can obviously protect immunologicalinjury to liver in rats.Its role mechanism is related with anti-lipid peroxidation.