2007•ZhongchengyaoRequires access

Determination of hesperidin and salvianolic acid B in Xiaopikang Capsule by HPLC

Junxiang Wang

Abstract

AIM: To determine the contents of hesperidin and salvianolic acid B in Xiaopikang Capsule(Folium Citri reticulatae,Radix et Rhizoma Salviae miltiorrhizae,etc.) by HPLC. METHODS: The HPLC system consisted of Diamonsil C_(18) column(250 mm×4.6 mm,5 μm), metanol-acetonitrile-formicacid-water(30∶10∶1∶59) mixture as mobile phase,detection wavelength at 284 nm,flow rate of 1.0 mL/min. RESULTS: The ca-(libration) curves of two ingredients were linear within the ranges of 0.22 μg-2.2 μg(r=0.999 6,hesperidin),(1.62 μg-10.2 μg)(r=0.999 9,salvianolic acid B),respectively.The average recoveries of hesperidin was(98.9%)(RSD=1.60%),salvianolic acid B for 99.02%(RSD=0.97%). CONCLUSION: The method is rapid,sensitive and accurate.

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Key concepts: Hesperidin, Chemistry, Chromatography, High-performance liquid chromatography, Capsule, Radix (gastropod), Alternative medicine, Pathology