The experimental study on relation between lipid levels of fatty liver and liver function

Objective To explore relation between lipid levels of fatty liver and liver function.Methods 64 SPF wistar rats were randomly divided into Group A,B,C,D,E and F.Group A,B,C,D and E were given high fat diet(84.4% standard food,10% lard,0.5% cholesterol,0.1% bile salt and 5% egg yolk powder)and wine to make fatty liver model of rats,group B,C,D and E were respectively given low,middle and high dose of Gankang Ⅳ(GKⅣ)and Dongbao Gantai gavaged intervention,and a control group F was set.After 6 weeks,rats were sacrificed and 10% liver homogenate was made from liver to test TC and TG,abdominal aortic blood was drawed to test ALT and AST.Results Compared with group A,TC and TG levels decreased significantly(P0.05～0.01),ALT and AST levels were significantly higher(P0.05～-0.01)in group B,C,D and E;Compared group C and D with E there was significant difference for TC and TG(P0.05);For ALT and AST,compared group C and D with E there was a very significant difference(P0.01).Conclusion GKⅣ can effectively reduce the liver lipid deposition;inhibit increasing of ALT and AST.From the indicators of ALT,AST,TC and TG,the deposition amount of TC and TG have a close relationship with ALT and AST.