2003•Tianjin Journal of Traditional Chinese MedicineRequires access
Influence of Chinese decoction Gengnianle on monoamine neurotransmitter in climacteric rats
Hong Liu
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Abstract
To study the influence on monoamine neurotransmitter in climacteric rats treated by Chinese decocˉtion Gengnianle with the effect of tonifying the kidney,smooth the liver and regulating and tonifying the Chong and Ren Channels.Twenty_five rats(age:11～15months)were randomly divided into model group and treatment group. Eight rats(age:3months)consisted of the young rat control group.The decoction was given to the treatment group while normal saline to the other two groups.Monoamine neurotransmitter at hypothalamus including NE,DA,5-HT,5-HIAA were detected by HPLT-electrochemical method. Gengnianle could decrease5-HT and5-HIAA(P0.01,P0.05),increase NE(P0.05)and make the ratio of5-HT/NE near to that of young rat control group(P0.01).[Conclusion] Chinese decoction Gengnianle can improve the function of hypothalamus through regulating the level of monoamine neurotransmitter.