Influence of edaravone on the serum levels of vWF and hs-CRP in patients with acute cerebral infarction

Objective To study the influence of edaravone on the serum levels of vWF and hs-CRP in patients with acute cerebral infarction.Methods 40 patients with acute cerebral infarction were randomly divided into routine group of 20 cases and edaravone group of 20 cases.All cases were given routine treatment,while the cases of edaravone group were added with edaravone 30mg,twice a day,totally14d.The serum levels of vWF and hs-CRP were investigated before and 7d after treatment and the sizes of the infarction on MRI were measured on 5d after treatment.The NIH scale and clinical outcome were evaluated before and 30d after treatment.Results The therapeutic efficacy of edaravone group was significantly better than that of routine group(P0.05).The serum levels of vWF of the edaravone group were lower than those of routine group on 7d(P0.01).Compared with control group,the serum levels of hs-CRP were the lowest on 7d(P0.01).The hs-CRP levels of middle and large infarction groups before treatment were higher than those of lacunar and small infarction groups(P0.05).Conclusion Our result indicates that edaravone can reduce the injury of ischemic brain cells and improve therapeutic efficacy probably through decreasing the serum level of vWF and hs-CRP.