Clinical significance of VEGF and TNFα in serum of normal pregnancies and patients with Preelaclampsia

Objective:To examine the level of TNFα and vascular endothelial growth factor(VEGF) in maternal serum of normal pregnancies and patients with preeclampsia and to study the clinical significance and effects of them on the pathogenesis of the disease.Methods:Serum levels of TNFα and VEGF of 40 normal pregnant women and 50 patients with preeclampsia(mild 20,severe 30) were determined respectively by radioimmunoassay and ELISA.Results:① Serum levels of VEGF in all preeclampsia subgroups(16.33±1.02) μg/L,(15.61±1.13) μg/L in mild and severe were significantly lower than those in the normal pregnant group(17.12±1.81) μg/L(P0.05).There was negative correlation between levels of VEGF and degrees of preeclampsia(r=-0.446,P0.05).②Serum levels of TNFα in preeclampsia(1.57±0.17) μg/L were significantly higher than that of normal pregnant group(1.39±0.13) μg/L.③There was negative correlation between levels of VEGF and TNFα(r=-0.448,P0.05) in preeclampsia and normal pregnant women.④There were close relationship in serum levels of VEGF and TNFα in patients of preeclampsia and their clinical characters.Conclusion:The levels of VEGF and TNFα maybe suggest the degree of preeclampsia,be one of the indicator of preeclampsia;VEGF may be correlated with TNFα in development of preeclampsia.