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Relationship among gene polymorphisma of angiotensinogen(AGT) gene T174M and essential hypertension and cerebral infarction

LI Hong-fe

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Abstract

【Objective】To study the relationship between the gene polymorphisma of angiotensinogen(AGT) gene T174M and cerebral infarction. 【Methods】Polymerase chain reaction(PCR) restriction fragment length polymor- phism(RFLP) was used to detected the gene polymorphisms of AGT gene 174 site in 396 cerebral infarction patients and 360 normal controls. Biochemical index of GLU was detected by auto-chiemical analyzer. 【Results】AGT gene 174TT genotypic(88.4%), TM genotypic(11.3%)(OR=2.070) and M allele(5.7%) in cerebral infarction group were significantly higher than those in normal control group(OR=2.005). The morbidities of EH were different between two gene types, the morbidity of EH was higher in TM type than the TT type. 【Conclusions】AGT gene 174TM Gene type has some relation of Essential Hypertension,AGT gene 174TM Gene type and M allele may be susceptible fac- tors.

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【Objective】To study the relationship between the gene polymorphisma of angiotensinogen(AGT) gene T174M and cerebral infarction. 【Methods】Polymerase chain reaction(PCR) restriction fragment length polymor- phism(RFLP) was used to detected the gene polymorphisms of AGT gene 174 site in 396 cerebral infarction patients and 360 normal controls. Biochemical index of GLU was detected by auto-chiemical analyzer. 【Results】AGT gene 174TT genotypic(88.4%), TM genotypic(11.3%)(OR=2.070) and M allele(5.7%) in cerebral infarction group were significantly higher than those in normal control group(OR=2.005). The morbidities of EH were different between two gene types, the morbidity of EH was higher in TM type than the TT type. 【Conclusions】AGT gene 174TM Gene type has some relation of Essential Hypertension,AGT gene 174TM Gene type and M allele may be susceptible fac- tors.

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Available abstract

【Objective】To study the relationship between the gene polymorphisma of angiotensinogen(AGT) gene T174M and cerebral infarction. 【Methods】Polymerase chain reaction(PCR) restriction fragment length polymor- phism(RFLP) was used to detected the gene polymorphisms of AGT gene 174 site in 396 cerebral infarction patients and 360 normal controls. Biochemical index of GLU was detected by auto-chiemical analyzer. 【Results】AGT gene 174TT genotypic(88.4%), TM genotypic(11.3%)(OR=2.070) and M allele(5.7%) in cerebral infarction group were significantly higher than those in normal control group(OR=2.005). The morbidities of EH were different between two gene types, the morbidity of EH was higher in TM type than the TT type. 【Conclusions】AGT gene 174TM Gene type has some relation of Essential Hypertension,AGT gene 174TM Gene type and M allele may be susceptible fac- tors.

Key concepts: Genotype, Gene, Allele, Cerebral infarction, Restriction fragment length polymorphism, Biology, Essential hypertension, Genetics

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