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2006•Chinese Journal of Birth Health & HeredityRequires access

The study of angiotensinogen gene M235T polymorphism with cerebral infarction in young and middle-aged adults.

Lijun Wang

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Abstract

Objective: To explore the relationship between angiotensinogen(AGT) gene M235T polymorphism and cerebral infarction in young and middle-aged adults.Methods: M235T polymorphism of AGT gene from peripheral blood leukocytes was examined in 62 cases with CI and 58 noninfarct controls by polymerase chain reaction(PCR) amplification and restriction fragment length polymorphism(RFLP).Results: The frequencies of AGT gene T235 allele and 235TT genetype were 79.84% and 64.52% respectively which are little higher than those of the control group(73.28% and 55.17% respectively).There is no statistical difference between them(χ~2=1.09,P=0.296;χ~2=1.443,P=0.230).Conclusions: There might be no association between AGT gene M235T and cerebral infarction in young and middle-aged adults.

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Objective: To explore the relationship between angiotensinogen(AGT) gene M235T polymorphism and cerebral infarction in young and middle-aged adults.Methods: M235T polymorphism of AGT gene from peripheral blood leukocytes was examined in 62 cases with CI and 58 noninfarct controls by polymerase chain reaction(PCR) amplification and restriction fragment length polymorphism(RFLP).Results: The frequencies of AGT gene T235 allele and 235TT genetype were 79.84% and 64.52% respectively which are little higher than those of the control group(73.28% and 55.17% respectively).There is no statistical difference between them(χ~2=1.09,P=0.296;χ~2=1.443,P=0.230).Conclusions: There might be no association between AGT gene M235T and cerebral infarction in young and middle-aged adults.

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Available abstract

Objective: To explore the relationship between angiotensinogen(AGT) gene M235T polymorphism and cerebral infarction in young and middle-aged adults.Methods: M235T polymorphism of AGT gene from peripheral blood leukocytes was examined in 62 cases with CI and 58 noninfarct controls by polymerase chain reaction(PCR) amplification and restriction fragment length polymorphism(RFLP).Results: The frequencies of AGT gene T235 allele and 235TT genetype were 79.84% and 64.52% respectively which are little higher than those of the control group(73.28% and 55.17% respectively).There is no statistical difference between them(χ~2=1.09,P=0.296;χ~2=1.443,P=0.230).Conclusions: There might be no association between AGT gene M235T and cerebral infarction in young and middle-aged adults.

Key concepts: Genotype, Restriction fragment length polymorphism, Polymorphism (computer science), Allele, Biology, Cerebral infarction, Gene, Gene polymorphism

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The study of angiotensinogen gene M235T polymorphism with cerebral infarction in young and middle-aged adults. — Research Paper | ScholarLens