Observation of Zishenqinggan decoction combined with telbivudine on chronic hepatitis B patients with liver-kidney Yin deficiency syndrome

Objective:To observe the clinical efficacy on the treatment of chronic hepatitis B,the syndrome of liver-kidney Yin deficiency by Zishenqinggan decoction combined with telbivudine.Methods:Sixty hepatitis B patients as research subjects,were randomly divided into two groups.The experimental group(30 cases) was treated with Zishenqinggan decoction combined with telbivudine,and the control group(30 cases) was treated with telbivudine alone.After 24 weeks′ treatment,the patient′s circumstance such as: clinical symptom,biochemical indicator,immunity target,virology target,and so on were observed and analysed.Results:After the treatment of 24 weeks,the total efficiency in the experimental group was 70.00%,which was 53.33% in the control group.Statistically,there was not significant difference between the two groups(P0.05),perhaps because of the short course.The experimental group was significantly better than the control group,in improving clinical symptom,biochemical indicator,immunity target,anti-viral response rate,which were statistically significantly different(P0.05).In the HBV DNA negative rate,HBeAg negative rate and HBeAg/HBeAb conversion rate,the two groups had not shown difference statistically(P0.05).Conclusion:The treatment method of Zishenqinggan decoction combined with telbivudine is safe and effective in clinical applications of chronic hepatitis B,the syndrome of liver-kidney Yin deficiency,not only in improving the symptoms of the patients,regulating their immunity and resuming their liver function,but also in enhancing anti-viral response rate.And it has not been found the obvious side effect.