Expression of PAX2 and PCNA in renal cell carcinoma

Objective To study the expression of PAX2,PCNA in Renal cell carcinoma and evaluate their biological significance.Methods The expression of PAX2 and PCNA were assayed by means of immunohistochemical technique in Rcc and normal renal tissues.Results The positive expression rates of PAX2 in Rcc and normal renal tissues were 63 6% and 18 2% respectively ( P 0 01).PAX2 expression was related to tumor stage,but not to tumor grade or cell subtype.The positive expression rates of PCNA in Rcc tissues were higher than those in normal renal tissues( P 0 01),and were related to tumor stage,grade,but not to cell subtype.There were no relations of expression between PAX2 and PCNA.Conclusion PAX2 and PCNA may be involved in the process of renal carcinogenesis and tumor progression.Their immunoreactivity may serve as an index of diagnosis and the malignant degree of Rcc.