Expression of ΔNp63 in Salivary Gland Tumours

Objective To detect the expression of ΔNp63 in human salivary gland tumor and analyze its role in the malignant salivary gland tumors. Methods Collecting the samples from 68 cases of pathologically proven salivary gland tumours and investigating the microscopic sections with HE stain and immunohistochemical-SP stain. Results It was found that the expression of ΔNp63 is gradually increased in the malignant tumours, the myoepithelial cells and the basal cells of the salivary gland tumors are positive, and the expression of ΔNp63 is correlated directly with benign and malignant tumor. Conclusion ΔNp63 plays an important role in salivary gland tumours. ΔNp63 possesses some special activity that is characteristic of oncogene. p63 is a sensitive and highly specific marker of myoepithelial cells in salivary gland tumours and an additional marker for defining myoepithelial histogenesis. p63 is of definite clinical value in falicitating diagnosis and differential diagnosis.