The Application of the Copeptin in the Risk Stratification of Non-ST Segment Elevation Acute Coronary Syndrome

OBJECTIVE To observe the application of the Copeptin in the risk stratification of non-ST segment elevation acute coronary syndrome.METHODS 120 patients with suspected non-ST segment elevation acute coronary syndrome within four hours of onset(named the NSTE-ACS Group) were collected in Cardiology of hospital,then randomly selected 40 healthy patients as a control group.The NSTE-ACS Group were grouped according to the method of the number of coronary lesions and coronary lesion in Gensini.The serum copeptin were detected respectively after onset 4h,12 h,24h,and compared with the control group.RESULT After onset 4h,12 h,24h,the serum copeptin was significantly higher than control group,the difference was statistically significant(P0.05).With the increase in the number of coronary artery,the Copeptin levels tended to increase,Pearson correlation analysis showed:Copeptin levels and the number of coronary lesions was positively correlated(r=0.714,P0.01).The difference between each two groups was statistically significant(F respectively was 4.56,5.87,5.65,P0.05).With the increasing degree of coronary stenosis,Copeptin levels also tended to increase,Pearson correlation analysis showed:Copeptin levels and the degree of coronary stenosis was positively correlated(r=0.741,P0.01).The difference between each two groups was statistically significant(F respectively was 4.56,5.87,5.65,P0.05).CONCLUSION The diagnostic sensitivity of Copeptin in non-ST segment elevation acute coronary syndrome was superior to sensitive troponin I,with a good diagnostic value,which was worthy of clinical application.