Angiostatin and endostatin as suppressors on tumor growth

Angiogenesis is a key limiting step in tumor growth and metastasis. The control of angiogenesis has emerged as an important mechanism of suppressing tumor growth. Recent discoveries of endogenous negative of regulators of angiogenesis--angiostatin and endostain suggest a new paradigm of tumorigenesis. This review is concerned about their identification?molecular biology?bioactivity, especially their antitumor effects. Although there remains some problems about their treatment for cancer, the studies of angiostain and endostain is likely to create a new therapeutic options.