Effects of atorvastatin on lipid modulation and non-lipid modulation in senile patients with blood lipid abnormality

Objective: To explore the effects of atorvastatin on modulating blood lipid and preventing urgent cardiocerebral vascular event.Methods:One hundred and fortythree senile patients more than 60 years with blood lipid abnormality were randomly divided into two groups. Seventythree patients in atorvastatin group were treated with atorvastatin 10 mg/d, and 70 patients in placebo group were treated with placebo 1 tablet as control. The therapeutic course was 1 year. The changes in blood lipids and the occurrence of acute cardiocerebral vascular event and side effects were observed. Results: Total cholesterol(TC), triglycerin (TG), low density lipoproteincholesterin(LDLC), and apolipoproteins (Apo) B were all significantly decreased (all P 0 01), while the high denstity lipoproteincholesterol(HDLC) and ApoA1 were all significantly increased (both P 0 01) after atrovastatin treatment, the differences being significant compared to the placebo control group(all P 0 01). Ratio of eligibility of total TC, LDLC, and TG were 80% , 78%, 60%, respectively in atorvastatin treatment group. Followup for 1 year showed that the incidence rate of unstable angina, nonlethal myocardial infarction, heart failure in the atorvastatin group were all significantly decreased (all P 0 05 ); and the mortalities due to stroke, arrhythmia, cardiopathy were all reduced in the two groups, and the side effects were slight. Conclusion: Atorvastatin is effective for treating blood lipid abnormality in senile patients , and the side effect is mild. Atorvastatin can effectively prevent urgent cardiocerebral vascular event because of its blood lipid modulating effect.