Effects of Atorvastatin on levels of C-response protein in sepsis rats

Objective To investigate the influences of atorvastatin on C-response protein( CRP) of rats with sepsis. To discuss whether the statins would affect the host response to inflammation. Methods Sepsis models were establishing using 100 male SD rats. The rats were manufactured models by cecal ligation and puncture( CLP). A total of 100 healthy rats randomly were divided into 4 groups( n = 25) : Sham-operation group,CLP group,low-dose atorvastatin group and high-dose atorvastatin group. Blood samples of five rats in each group were collected at postoperative 0,3,6,12 and 24 hours to detect CRP in plasma. We observed and compared the activity of rats in each group. Specimens of small intestine were taken for pathological examination by optical microscope. Results At 0 h,plasma CRP levels were not significantly different among the groups. CRP levels in low-dose and high-dose atorvastatin groups were both significantly lower at postoperative 3,6,12 and 24 hours( P 0. 01) than those in CLP group. CRP levels in high-dose atorvastatin group were significantly lower than those in low-dose group( P 0. 01) at the four time points. Conclusion Atorvastatin could inhibit the expression of CRP in blood plasma of sepsis rats,and might have anti-septic effect.