Influence of atorvastatin to the nitric oxide in blood plasma of sepsis rats

[Objective] To investigate the influence of atorvastatin on nitric oxide(NO) in blood plasma of sepsis rats.[Methods] A total of 75 male rats were randomized in control group,sepsis group and atorvastatin group(n=25).The rats were treated with sham-operation in control group,with(CPL) in sepsis group,and feeded on 40 mg kg-1 atorvastatin with intragastric administration before CPL in atorvastatin group.The blood of the rats were colleced in postoperative 0 h,2 h,6 h,10 h,24 h in the groups.The levels of NO were detected with the spectrophotometera.The specimen of the lung and jejunum of the rats were pathological examination.[Results] The level of NO significantly increases in sepsis group at postoperative 6h and get peak(329.04±21.14)μmol/L at 24 h.The level of NO increases in atorvastatin group at postoperative 10h and get peak(209.53±10.68)μmol/L at 24 h.Compared with the sepsis group,the levels of NO in atorvastatin group were significantly lower(P0.01) at 6 h,10 h and 24 h.Hyperemia,necrosis and exudate on the specimen of the lung and jejunum were shown in sepsis group,but were reduced in atorvastatin group.[Conclusions] Atorvastatin may postpone of the NO in blood plasma in sepsis rats and reduce inflammatory reaction.