Analysis of distribution and antibiotic resistance of pathogens isolated from blood specimens of neonates

Objective:To investigate distribution and antibiotic resistance of pathogens causing neonatal septicemia to provide evidence for reasonable use of antibiotics.Methods:The data of isolate distribution and antibiotic resistance of pathogens collected from blood specimens of neonate septicemia patients from July 2006 to July 2009 were analyzed retrospectively.Results:185 pathogenic strains were isolated from 4274 blood specimens,and the positive rate was 4.3%.Of the 185 isolates,171 strains were gram-positive bacteria(92.4%),and the strains of coagulase negative staphylococci(CNS) were frequently detected(151 isolates),followed by Staphylococcus aureus(9 isolates) and Enterococcus(6 isolates);Only 14(7.6%) gram-negative strains were isolated,and escherichia coli and Klebsiella pneumoniae ranked in top two.The resistance rate of staphylococci to penicillin was high(93.2%),followed by eryhhromycin(83.8%),cefazolin(82.6%),oxacillin(72.6%) and ampinicillin/sulbactam(67.7%).The resistance rate of gram-negative baeteria to ampinicillin was 100%,and the percentage of resistance to cefazolin,amoxicillin,ticarcillin was more than 50%.Conclusion:CNS is the primary pathogens of blood cultures in newborns,and is of higher resistance rate to penicillin,eryhhromycin,oxacillin,cefazolin and ampinicillin/sulbactam.Therefore,to help clinicians prescribe antibacterial drugs reasonably for the treatment of neonate septicemia,it is necessary to monitor the distribution and the resistance of pathogens isolated from blood samples of this kind of patients.