2011•Fine Chemical IntermediatesRequires access
One-pot synthesis of O-methyl-N-nitroisourea
Luo Liang-ming
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Abstract
O-methyl-N-nitroisourea was synthesized in a one-pot procedure using urea,dimethyl sulfate,nitric acid and sulfuric acid as raw materials.The effect of reaction temperature and time,catalyst and raw material propotioning on the reaction yield was studied,so that a more excellent reaction condition could be determined: under a molar ratio n(1)∶n(2) of 1.3:1;at 70℃;by a catalyst of 50% sulfuric acid for 4 h.The total yield was 43%,and the content was more than 99%.